Nau's Homestay 2 is in District 4, a riverside district close to the centre of Ho Chi Minh City, about 1.3 km from the city centre. The property is on Đoàn Văn Bơ street, where small eateries cluster around it: the cafés Xing Fu Tang, Nuoc Ep Sinh To Detox and Happy Juice are 100 m away, and the restaurants Gỏi Cuốn Mẹ Su, Quán Cô Bảy and Bún Bò Huế Chiến Mập are 50 m away. The historic Nha Rong Wharf, a riverside landmark, is 700 m away.
Tan Son Nhat International Airport is 6.7 km away and sits in Tan Binh, north-west of the centre. Saigon Railway Station, the main long-distance train station, is 3.6 km away, and Ben Thanh Station, on Metro Line 1, is 1.1 km away. The Sai Gon Hydrofoil Terminal is 1 km away and Bến Bạch Đằng, a ferry terminal, is 1.5 km away.
For sightseeing, the Fine Arts Museum, housed in a colonial-era building, is 950 m away and the Ho Chi Minh Museum is 700 m. The War Remnants Museum, which documents the Vietnam War, is 2.3 km away, Tao Dan Park 1.8 km and the Zoo and Botanical Garden Ho Chi Minh 2.8 km. Chùa Tân Phước pagoda is 150 m away, and the markets at Xom Chieu and Hang Phan, 250 m and 400 m away, sell fresh food for the day. Bach Dang Wharf Park is 1 km away and Crescent Lake 4.3 km.